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4-Hydroxy-2-nonenal (HNE) is implicated as a neurotoxic 'second messenger' of oxidative damage in Alzheimer's disease (AD). The mechanism of HNE toxicity is due to alkylation of cellular nucleophilic groups. The C1 aldehyde is key to the alkylation ability of HNE. Oxidation of the C1 aldehyde to 4-hydroxy-2-nonenoic acid is catalyzed by aldehyde dehydrogenases. In this work, we tested the hypothesis...
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