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Trypanosoma brucei Pteridine reductase (TbPTR1) is of vital importance and is an established drug target for dreaded Human African trypanosomiasis (HAT). Pharmacophore perception strategy has been employed to identify key chemical features responsible for the biological activity for TbPTR1. The findings suggest that three different pharmacophore features can be associated with T. brucei anti‐PTR1...
Tuberculosis remains one of the most dreaded infectious diseases notwithstanding the availability of a number of anti‐tuberculosis drugs. The recent rise of multidrug‐resistant tuberculosis and its association with HIV infection poses a challenging health concern. Therefore, there exists a pressing requirement to identify novel drug targets and develop new anti‐tuberculosis drugs that will be effective...
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