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Background & Aims: The rate of 12α-hydroxylation of bile acid intermediates is believed to determine the ratio of cholic acid (CA) to chenodeoxycholic acid (CDCA) biosynthesis and the overall hydrophobicity of the bile acid pool. The aim of this study was to determine the effects of the level of expression of sterol 12α-hydroxy-lase (CYP8b1) and cholesterol 7α-hydroxylase (CYP7a1) on rates of...
Background & Aims: Sterol 12α-hydroxylase (CYP8b1) is required for the biosynthesis of cholic acid (CA) and hence helps determine the ratio of CA to chenodeoxycholic acid (CDCA) in bile. This study examined the in vivo regulation of CYP8b1 in the rat by bile acids, cholesterol, and thyroxine. Methods: The specific activities (SAs), messenger RNA (mRNA) levels, and transcriptional activities of...
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