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In order to decode the roles that N-methyl-d-aspartate (NMDA) receptors play in excitatory neurotransmission, synaptic plasticity, and neuropathologies, there is need for ligands that differ in their subtype selectivity. The conantokin family of Conus peptides is the only group of peptidic natural products known to target NMDA receptors. Using a search that was guided by phylogeny, we identified new...
The M-superfamily of conotoxins currently comprises three major groups of peptides (the μ-, κΜ-, and ψ-families) that share a key structural characteristic, the six-cysteine motif CC–C–C–CC, but differ with respect to their molecular targets. The ψ-family consists of M-superfamily conotoxins that are nicotinic acetylcholine receptor (nAChR) antagonists. To date, only two ψ-conotoxins, PIIIE and PIIIF,...
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