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α-Hemolysin, secreted fromStaphylococcus aureusas a water-soluble monomer of 33.2 kDa, assembles on cell membranes to form transmembrane, heptameric channels. The structure of the detergent-solubilized heptamer has been determined by X-ray crystallography to 1.9 Å resolution. The heptamer has a mushroom-like shape and measures up to 100 Å in diameter and 100 Å in height. Spanning the length of the...
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