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Pathogenic Vibrio cholerae secrete V.cholerae cytolysin (VCC), an 80kDa pro-toxin that assembles into an oligomeric pore on target cell membranes following proteolytic cleavage and interaction with cell surface receptors. To gain insight into the activation and targeting activities of VCC, we solved the crystal structure of the pro-toxin at 2.3Å by X-ray diffraction. The core cytolytic domain of VCC...
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