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Intentional weight loss is an important treatment option for overweight persons with type 2 diabetes mellitus (DM), but the effects on long‐term fracture risk are not known. The purpose of this Look AHEAD analysis was to evaluate whether long‐term intentional weight loss would increase fracture risk in overweight or obese persons with DM. Look AHEAD is a multicenter, randomized clinical trial. Recruitment...
Objective
To test the hypothesis that an 8‐year intensive lifestyle intervention (ILI) suppresses aging‐dependent changes in regional lean mass (LM) and fat mass (FM) among people with overweight/obesity and type 2 diabetes.
Methods
Regional body composition was measured by dual‐energy X‐ray absorptiometry within a subset of 1,019 volunteers (45–75 years old) in the Look AHEAD study randomized...
High‐density lipoproteins (HDLs) are antiatherogenic through their role in reverse cholesterol transport (RCT), that is, the transfer of cholesterol from macrophages in the subendothelial space of the arterial wall to HDL carriers to the liver for disposal. Many mechanisms that increase HDL are not atheroprotective; enhancing RCT via improved cholesterol efflux or esterification is not clearly atheroprotective...
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