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We sought to determine if different β-adrenergic receptor (βAR) subtypes, and their associated signalling machinery, are functionally localized to nuclear membranes.Employing enriched nuclear preparations, we assayed the specific presence of βAR by measuring 125 I-cyanopindolol (CYP) binding, Western blotting, confocal microscopy and functional assays.Western blots of rat heart nuclear fractions...
In vitro, little specificity is seen for modulation of effectors by different combinations of Gβγ subunits from heterotrimeric G proteins. Here, we demonstrate that the coupling of specific combinations of Gβγ subunits to different receptors leads to a differential ability to modulate effectors in vivo. We have shown that the β 1 AR and β 2 AR can activate homomultimers of the human...
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