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In response to a low environmental pH and with the help of the B fragment (DTB) the catalytic domain of diphtheria toxin (DTA) crosses the endosomal membrane to inhibit protein synthesis. In this study, we investigated the interaction of DTA with lipid membranes by biochemical and biophysical approaches. Data obtained from proteinase K and trypsin digestion experiments of membrane-inserted DTA suggested...
Like diphtheria toxin and the N-terminal (M r 23 000) region of fragment B, CB1 (M r 13 000), the cyanogen bromide peptide located in the middle region of fragment B is able to induce pore formation in lipid bilayer membrane at low pH. These two peptides (M r 23 000 and 13 000) share a common segment (M r 6300) containing the predicted amphipathic, α-helical, transverse...
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