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Intracellular proteolytic processing of bovine leukemia virus (BLV) envelope glycoprotein precursor (gp72) at the C-terminal end of the RVRR 268 ↓ site is an essential step for virus infectivity. Subtilisin/kexin-like convertases cleave proproteins at preferred RX(K/R)R↓ sites, including those commonly found in viral envelope glycoprotein precursors. We first demonstrated that gp72 is processed...
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