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The cyclophilin (Cyp) inhibitors – cyclosporine A (CsA), NIM811, Debio 025, and SCY 635 – block HCV replication both in vitro and in vivo, and represent a novel class of potent anti-HCV agents. We and others showed that HCV relies on cyclophilin A (CypA) to replicate. We demonstrated that the hydrophobic pocket of CypA, where Cyp inhibitors bind, and which controls the isomerase activity of CypA,...
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