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α1-Adrenoceptors in most tissues couple with the heterotrimeric GTP-binding protein Gq, the α subunit of which activate the β-isoforms of phospholipase C. However, in heart (and in liver) α1-adrenoceptors have been reported to couple to a high molecular weight GTP-bindingprotein, Gh, which functions both as a type II transglutaminase and as a receptor coupling protein. Gh activates a phospholipase...
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