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Factors determining the in vivo uptake of radiolabeled somatostatin analogs by neuroendocrine tumors are poorly known. The aim is to evaluate in vivo tumor perfusion and regulation of somatostatin receptors (sstr) following acute exposure to octreotide, in an animal model of neuroendocrine tumor.H 215 O flow studies were performed in 8 CA20948 tumor-bearing rats and another 36 rats underwent...
Abstract. As scintigraphy with [111In-DTPA0]octreotide has become a standard technique in analysing somatostatin receptor-receptor positive lesions such as neuroendocrine tumours, a logical next step is peptide receptor radionuclide therapy (PRRT). Initial studies on PRRT were performed with high doses of [111In-DTPA0]octreotide, and recently other radionuclides coupled to other somatostatin analogues...
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