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Farnesyl-O-acetylhydroquinone (IC 50 =2.5μmol/l) suppressed the proliferation of murine B16F10 melanoma cells with a potency much greater than those of farnesol (IC 50 =45μmol/l) and farnesyl anthranilate (IC 50 =46μmol/l), its alcohol, and ester counterparts with proven anti-tumor activities in vivo. Geranyl-O-acetylhydroquinone (IC 50 =5.1μmol/l)...
The numbers of isoprene residues and unsaturated bonds, cis/trans configuration, and head group polarity influence the tumor-suppressive potency of acyclic isoprenoid hydrocarbons and alcohols; within the series tested, trans, trans farnesol had the greatest potency. Geraniol esters had increased potency relative to that of the free alcohol. Farnesyl anthranilate induced a concentration-dependent...
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