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Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected...
A dynamic kinetic resolution is utilized to realize highly diastereoselective nucleophilic displacement of bromine in tert-butyl (4S)-1-methyl-3-(2-bromoacyl)-2-oxoimidazolidine-4-carboxylates (6a-f) by benzylamine enroute to tert-butyl (4S)-1-methyl-3-(2-benzyaminoacyl)-2-oxoimidazolidine-4-carboxylates (7a-e).
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