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The cDNA for mouse NAD + dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) was isolated from a lung cDNA library. The cDNA contains a 798 bp open reading frame that codes for a protein of 266 amino acids (M r 28 775) which shares 87% identity with the human 15-PGDH protein. The regions that are believed to form the NAD + binding site and the active site are conserved...
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