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We report the use of a sensitive double-clad fiber (DCF) probe for remote cell flow velocity measurement by the means of two-photon excited fluorescence correlation spectroscopy (FCS). The ability to measure the flow velocities of labeled cells in whole blood has been demonstrated. A flow velocity of as high as 40 cm/s has been measured. The theoretical lower limit is the self-diffusion of the cell,...
With a highly sensitive one dimensional photonic crystal biosensor, we have demonstrated quantitative real-time label-free detection of DNA oligomers, including binding to protein, concentration detection limits, and base-mismatched hybridization.
We report the use of a dual-clad optical fiber for two-photon excited fluorescence correlation spectroscopy. The ability to detect nanoparticles has been demonstrated. This technique shows the potential of conducing FCS measurements in vivo.
We report a novel sensor for label-free biomolecular assay using a one-dimensional photonic crystal in a total-internal-reflection geometry. This configuration creates a unique open biosensing interface for real-time detection with ultrahigh sensitivity.
We report the use of a dual-clad optical fiber for two-photon excited fluorescence correlation spectroscopy. The ability to detect nanoparticles has been demonstrated. This technique shows the potential of conducing FCS measurements in vivo.
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