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The polymer OEI-HD-1, a degradable 25kDa carrier for siRNA transfer based on β-propionamide-crosslinked oligoethylenimine, was functionalized to further improve biocompatibility and/or endosomolytic characteristics of the polymer. For this purpose OEI-HD-1 was either modified with succinic acid to reduce cationic charge density; alternatively OEI-HD-1 was grafted with 1molar equivalent of 5kDa polyethyleneglycol...
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