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Nanoparticle-mediated siRNA delivery is a promising therapeutic approach, however, the processes required for transport of these materials across the numerous extracellular and intracellular barriers are poorly understood. Efficient delivery of siRNA-containing nanoparticles would ultimately benefit from an improved understanding of how parameters associated with these barriers relate to the physicochemical...
A family of cationic Pluronic‐based polyrotaxanes (PR+), threaded with 2‐hydroxypropyl‐β‐cyclodextrin (HPCD), was synthesized for pDNA delivery into multiple cell lines. All PR+ formed highly stable, positively charged pDNA complexes that were < 250 nm in diameter. The cellular uptake and pDNA transfection efficiencies of the PR+:pDNA complexes was enhanced relative to the commercial transfection...
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