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Novel organic–inorganic hybrid nanoparticles consisting of polymer–hydrogel nanoparticles (nanogels) and iron oxide were developed for potential biomedical applications. Hybrid nanoparticles were prepared by a simple procedure using polysaccharide nanogels as a reactive site for iron oxide formation. The hybrid nanoparticles have a narrow size distribution with a diameter of approximately 30 nm and...
The interaction between bovine serum albumin (BSA) and a hydrogel nanoparticle formed by the self-aggregation of cholesterol-bearing pullulan (CHP) was investigated by using an isothermal titration microcalorimeter. In water, one nanoparticle of the CHP self-aggregates strongly bound approximately one BSA molecule. The heats associated with the complexation were exothermic. The complexation is enthalpically,...
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