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BACKGROUNDCastration‐resistant prostate cancer (CRPC) is a leading cause of cancer‐related deaths in elder men. This disease has limited therapeutic options and poor prognosis as the underlying molecular mechanisms are not clearly understood. Given the emerging roles of microRNA (miRNA) as a key regulator, we postulated that miRNA may play a significant role in CRPC formation.
METHODSmiR‐146a levels...
BACKGROUNDA G > C polymorphism (rs2910164) which is located in the sequence of miR‐146a precursor, results in a change from a G:U pair to a C:U mismatch in its stem region. To explore whether rs2910164 plays any role in prostate cancer (CaP), we analyzed the association between miR‐146a polymorphism and risk of CaP and the expression of miR‐146a with different genotypes in CaP tissues in southern...
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