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Although hyperthermia has been used as a treatment of malignant brain tumors, it is not yet clear what is the mechanism of the cell growth inhibition by heat shock, especially by the temperature which has clinically been applied to tumor–brain border-zone, 42–43°C. Therefore, we evaluated the change of U251-MG and U87-MG human malignant glioma cells after 43°C-heat shock comparing with that of 45°C...
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