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The induction of an undesirable immune response is a common problem encountered by biologic therapeutics, which can lead to poor clinical outcomes and life‐threatening adverse reactions. The zwitterionic nanocages for protein encapsulation developed by Shaoyi Jiang and co‐workers in article number 1705728 completely prevent the humoral immune response from either protein or polymer and overcome the...
For biotherapeutics that require multiple administrations to fully cure diseases, the induction of undesirable immune response is one common cause for the failure of their treatment. Covalent binding of hydrophilic polymers to proteins is commonly employed to mitigate potential immune responses. However, while this technique is proved to partially reduce the antibodies (Abs) reactive to proteins,...
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