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Mouse prostaglandin EP3 receptor consists of three isoforms, EP3α, β and γ, with different carboxy-terminal tails. To assess the role of their carboxy-terminal tails in membrane targeting, we examined subcellular localization of myc-tagged EP3 isoforms expressed in MDCK cells. Two isoforms, EP3α and EP3β, were localized in the intracellular compartment but not in the plasma membrane, while the EP3γ...
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