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(1) The role of L-type Ca 2+ channels in the relaxation to nitric oxide (NO)-mediated MaxiK Ca channel activation was examined in guinea pig aorta. (2) Acetylcholine (ACh) produced an endothelium-dependent relaxation of guinea pig aorta precontracted with noradrenaline (NA), which was abolished by an NO synthase inhibitor, N G -nitro-l-arginine (l-NNA). (3) Both endothelium-dependent...
Vasorelaxant effects of ATP-sensitive potassium (K ATP ) channel openers were examined on the tonic phase of vascular contraction induced by norepinephrine (NE) in guinea pig and rat aorta. K ATP channel openers, NIP-121 and cromakalim, produced glibenclamide-sensitive and concentration-dependent relaxations in guinea pig and rat aorta preconstricted with NE. ...
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