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Many species of pathogenic gram‐positive bacteria display covalently crosslinked protein polymers (called pili or fimbriae) that mediate microbial adhesion to host tissues. These structures are assembled by pilus‐specific sortase enzymes that join the pilin components together via lysine‐isopeptide bonds. The archetypal SpaA pilus from Corynebacterium diphtheriae is built by the CdSrtA pilus‐specific...
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