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A series of novel derivatives of 21E-benzylidene-pregn-1,4-diene-3,20-dione 7a–g and 21E-benzylidene-4-chloro-pregn-1,4-diene-3,20-dione 8a–g was synthesized from the commercially available progesterone. These title compounds were evaluated for their cytotoxic activity against brine shrimp (Artemia salina) and murine Lewis lung carcinoma cells (LLC). It was found that compounds 7a–g exhibited stronger...
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