Search results for: Richard N. Zare

Items from 1 to 20 out of 162 results

article

Coulometry‐assisted quantitation in spray ionization mass spectrometry

Xiaowei Song, Hao Chen, Richard N. Zare

Journal of Mass Spectrometry > 56 > 4 > n/a - n/a

The concentration of target analyte in a mixture can be quantified by combining coulometric measurements with spray ionization mass spectrometry. A three‐electrode system screen printed on the polymer support acts both as the coulometry platform for electrochemical oxidation and the sample loading tip for spray ionization. After loading a droplet of the analyte solution onto the tip, two steps were...

article

Identification of diagnostic metabolic signatures in clear cell renal cell carcinoma using mass spectrometry imaging

Kanchustambham Vijayalakshmi, Vishnu Shankar, Ryan M. Bain, Rosalie Nolley, more

International Journal of Cancer > 147 > 1 > 256 - 265

Clear cell renal cell carcinoma (ccRCC) is the most common and lethal subtype of kidney cancer. Intraoperative frozen section (IFS) analysis is used to confirm the diagnosis during partial nephrectomy. However, surgical margin evaluation using IFS analysis is time consuming and unreliable, leading to relatively low utilization. In our study, we demonstrated the use of desorption electrospray ionization...

article

Chemoselective N‐Alkylation of Indoles in Aqueous Microdroplets

Elumalai Gnanamani, Xin Yan, Richard N. Zare

Angewandte Chemie International Edition > 59 > 8 > 3069 - 3072

Many reactions show much faster kinetics in microdroplets than in the bulk phase. Most reported reactions in microdroplets mirror the products found in bulk reactions. However, the unique environment of microdroplets allows different chemistry to occur. In this work, we present the first chemoselective N‐alkylation of indoles in aqueous microdroplets via a three‐component Mannich‐type reaction without...

article

Chemoselective N‐Alkylation of Indoles in Aqueous Microdroplets

Elumalai Gnanamani, Xin Yan, Richard N. Zare

Angewandte Chemie > 132 > 8 > 3093 - 3096

article

Absolute Quantitation of Oxidizable Peptides by Coulometric Mass Spectrometry

Pengyi Zhao, Richard N. Zare, Hao Chen

Journal of The American Society for Mass Spectrometry > 2019 > 30 > 11 > 2398-2407

Quantitation methods for peptides using mass spectrometry have advanced rapidly. These methods rely on using standard and/or isotope-labeled peptides, which might be difficult or expensive to synthesize. To tackle this challenge, we present a new approach for absolute quantitation without the use of standards or calibration curves based on coulometry combined with mass spectrometry (MS). In this approach,...

article

The CM carbonaceous chondrite regolith Diepenveen

Marco Langbroek, Peter Jenniskens, Leo M. Kriegsman, Henk Nieuwenhuis, more

Meteoritics & Planetary Science > 54 > 7 > 1431 - 1461

A carbonaceous chondrite was recovered immediately after the fall near the village of Diepenveen in the Netherlands on October 27, 1873, but came to light only in 2012. Analysis of sodium and poly‐aromatic hydrocarbon content suggests little contamination from handling. Diepenveen is a regolith breccia with an overall petrology consistent with a CM classification. Unlike most other CM chondrites,...

article

Selective Synthesis in Microdroplets of 2‐Phenyl‐2,3‐dihydrophthalazine‐1,4‐dione from Phenyl Hydrazine with Phthalic Anhydride or Phthalic Acid

Dan Gao, Feng Jin, Xin Yan, Richard N. Zare

Chemistry – A European Journal > 25 > 6 > 1466 - 1471

Pyridazine derivatives are privileged structures because of their potential biological and optical properties. Traditional synthetic methods usually require acid or base as a catalyst under reflux conditions with reaction times ranging from hours to a few days or require microwave assistance to induce the reaction. Herein, this work presents the accelerated synthesis of a pyridazine derivative, 2‐phenyl‐2,3‐dihydrophthalazine‐1,4‐dione...

article

Nanomaterial Preparation by Extrusion through Nanoporous Membranes

Peng Guo, Jing Huang, Yaping Zhao, Charles R. Martin, more

Small > 14 > 18 > n/a - n/a

Template synthesis represents an important class of nanofabrication methods. Herein, recent advances in nanomaterial preparation by extrusion through nanoporous membranes that preserve the template membrane without sacrificing it, which is termed as “non‐sacrificing template synthesis,” are reviewed. First, the types of nanoporous membranes used in nanoporous membrane extrusion applications are introduced...

article

Microdroplets Accelerate Ring Opening of Epoxides

Yin-Hung Lai, Shyam Sathyamoorthi, Ryan M. Bain, Richard N. Zare

Journal of The American Society for Mass Spectrometry > 2018 > 29 > 5 > 1036-1043

The nucleophilic opening of an epoxide is a classic organic reaction that has widespread utility in both academic and industrial applications. We have studied the reaction of limonene oxide with morpholine to form 1-methyl-2-morpholino-4-(prop-1-en-2-yl) cyclohexan-1-ol in bulk solution and in electrosprayed microdroplets with a 1:1 v/v water/methanol solvent system. We find that even after 90 min...

article

Formation of Polymeric Nanocubes by Self‐Assembly and Crystallization of Dithiolane‐Containing Triblock Copolymers

Katherine Margulis, Xiangyi Zhang, Lydia‐Marie Joubert, Karsten Bruening, more

Angewandte Chemie International Edition > 56 > 51 > 16357 - 16362

Template‐free fabrication of non‐spherical polymeric nanoparticles is desirable for various applications, but has had limited success owing to thermodynamic favorability of sphere formation. Herein we present a simple way to prepare cubic nanoparticles of block copolymers by self‐assembly from aqueous solutions at room temperature. Nanocubes with edges of 40–200 nm are formed spontaneously on different...

article

Formation of Polymeric Nanocubes by Self‐Assembly and Crystallization of Dithiolane‐Containing Triblock Copolymers

Katherine Margulis, Xiangyi Zhang, Lydia‐Marie Joubert, Karsten Bruening, more

Angewandte Chemie > 129 > 51 > 16575 - 16580

article

“On‐Droplet” Chemistry: The Cycloaddition of Diethyl Azodicarboxylate and Quadricyclane

Ryan M. Bain, Shyam Sathyamoorthi, Richard N. Zare

Angewandte Chemie > 129 > 47 > 15279 - 15283

Sharpless and co‐workers previously studied the [2σ+2σ+2π] cycloaddition of diethyl azodicarboxylate (DEAD) and quadricyclane and reported that the addition of water to the neat reagents caused an acceleration in the reaction rate, giving birth to what has been called “on‐water” chemistry. We have examined the same reaction in aqueous microdroplets (ca. 5 μm diameter) and find that the cycloaddition...

article

“On‐Droplet” Chemistry: The Cycloaddition of Diethyl Azodicarboxylate and Quadricyclane

Ryan M. Bain, Shyam Sathyamoorthi, Richard N. Zare

Angewandte Chemie International Edition > 56 > 47 > 15083 - 15087

article

Polymer‐spray mass spectrometric detection and quantitation of hydrophilic compounds and some narcotics

Maria T. Dulay, Richard N. Zare

Rapid Communications in Mass Spectrometry > 31 > 19 > 1651 - 1658

Rationale High‐throughput screening of biofluids is essential in monitoring concentration of a variety of drugs to determine their efficacy and toxicity. Organosiloxane polymers prepared by sol‐gel chemistry as sample supports, and electrospray ionization emitters in a single material and as an alternative to paper substrates, is described in this study. Methods Hydrophobic drugs and hydrophilic...

article

Metabolic aging by MYC: Distinct lipid accumulation and phospholipid suppression by MYC in lungs and kidneys detected by Desorption Electro Spray Ionization Mass Spectrometry Imaging (DESI-MSI)

Arvin M. Gouw, Katy Margulis, Richard N. Zare, Dean W. Felsher

Experimental Gerontology > 2017 > 94 > C > 117

article

Introducing mass spectrometry to first-year undergraduates: Analysis of caffeine and other components in energy drinks using paper-spray mass spectrometry

Mahima Sneha, Maria T. Dulay, Richard N. Zare

International Journal of Mass Spectrometry > 2017 > 418 > C > 156-161

We describe the use of ambient ionization mass spectrometry in a freshman-level undergraduate class for the detection of caffeine and other components in several commercially available energy drinks (5-hour Energy, Starbucks Refreshers, Red Bull Sugarfree, and Coca Cola Classic). We use the technique of paper-spray mass spectrometry where a filter paper is used as a substrate on which a sample is...

article

Two‐Phase Reactions in Microdroplets without the Use of Phase‐Transfer Catalysts

Xin Yan, Heyong Cheng, Richard N. Zare

Angewandte Chemie International Edition > 56 > 13 > 3562 - 3565

Many important chemical transformations occur in two‐phase reactions, which are widely used in chemical, pharmaceutical, and polymer manufacturing. We present an efficient method for performing two‐phase reactions in microdroplets sheared by sheath gas without using a phase‐transfer catalyst. This avoids disadvantages such as thermal instability, high cost, and, especially, the need to separate and...

article

Two‐Phase Reactions in Microdroplets without the Use of Phase‐Transfer Catalysts

Xin Yan, Heyong Cheng, Richard N. Zare

Angewandte Chemie > 129 > 13 > 3616 - 3619

article

A Study of Heterogeneous Catalysis by Nanoparticle‐Embedded Paper‐Spray Ionization Mass Spectrometry

Shibdas Banerjee, Chanbasha Basheer, Richard N. Zare

Angewandte Chemie > 128 > 41 > 12999 - 13003

We have developed nanoparticle‐embedded paper‐spray mass spectrometry for studying three types of heterogeneously catalyzed reactions: 1) Palladium‐nanoparticle‐catalyzed Suzuki cross‐coupling reactions, 2) palladium‐ or silver‐nanoparticle‐catalyzed 4‐nitrophenol reduction, and 3) gold‐nanoparticle‐catalyzed glucose oxidation. These reactions were almost instantaneous on the nanocatalyst‐embedded...

article

A Study of Heterogeneous Catalysis by Nanoparticle‐Embedded Paper‐Spray Ionization Mass Spectrometry

Shibdas Banerjee, Chanbasha Basheer, Richard N. Zare

Angewandte Chemie International Edition > 55 > 41 > 12807 - 12811

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INFONA - science communication portal

Search results for: Richard N. Zare

Coulometry‐assisted quantitation in spray ionization mass spectrometry

Identification of diagnostic metabolic signatures in clear cell renal cell carcinoma using mass spectrometry imaging

Chemoselective N‐Alkylation of Indoles in Aqueous Microdroplets

Chemoselective N‐Alkylation of Indoles in Aqueous Microdroplets

Absolute Quantitation of Oxidizable Peptides by Coulometric Mass Spectrometry

The CM carbonaceous chondrite regolith Diepenveen

Selective Synthesis in Microdroplets of 2‐Phenyl‐2,3‐dihydrophthalazine‐1,4‐dione from Phenyl Hydrazine with Phthalic Anhydride or Phthalic Acid

Nanomaterial Preparation by Extrusion through Nanoporous Membranes

Microdroplets Accelerate Ring Opening of Epoxides

Formation of Polymeric Nanocubes by Self‐Assembly and Crystallization of Dithiolane‐Containing Triblock Copolymers

Formation of Polymeric Nanocubes by Self‐Assembly and Crystallization of Dithiolane‐Containing Triblock Copolymers

“On‐Droplet” Chemistry: The Cycloaddition of Diethyl Azodicarboxylate and Quadricyclane

“On‐Droplet” Chemistry: The Cycloaddition of Diethyl Azodicarboxylate and Quadricyclane

Polymer‐spray mass spectrometric detection and quantitation of hydrophilic compounds and some narcotics

Metabolic aging by MYC: Distinct lipid accumulation and phospholipid suppression by MYC in lungs and kidneys detected by Desorption Electro Spray Ionization Mass Spectrometry Imaging (DESI-MSI)

Introducing mass spectrometry to first-year undergraduates: Analysis of caffeine and other components in energy drinks using paper-spray mass spectrometry

Two‐Phase Reactions in Microdroplets without the Use of Phase‐Transfer Catalysts

Two‐Phase Reactions in Microdroplets without the Use of Phase‐Transfer Catalysts

A Study of Heterogeneous Catalysis by Nanoparticle‐Embedded Paper‐Spray Ionization Mass Spectrometry

A Study of Heterogeneous Catalysis by Nanoparticle‐Embedded Paper‐Spray Ionization Mass Spectrometry

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