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Purpose. A systematic study to assess the influence of N-oxygenation on the lipophilicity of aromatic weak bases was performed. Methods. The methods used were experimental (CPC and shake-flask techniques) and computational (AM1 semi-empirical method). Results. The intrinsic increment in the log Poct system for an oxygen atom added to form an aromatic N-oxide, designated as diff(log PN(O)−N...
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