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The ability of subtype-preferring α 2 -adrenoceptor antagonists to enhance the neurochemical effects of the antidepressant, fluoxetine, was evaluated by in vivo microdialysis. Combining the selective α 2A -adrenoceptor antagonist, BRL-44408 (10 mg/kg, s.c.), with fluoxetine (30 mg/kg, s.c.) elevated the extracellullar levels of serotonin (5-HT) and noradrenaline in the rat frontal...
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