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It is generally accepted that the availability of vitamin K in vivo depends on its homologues, the biological activities of which would differ among organs. To test this hypothesis, we examined the uptake, metabolism, and utilization of menaquinone-4 (MK-4) and phylloquinone (PK) using 18 O-labeled compounds in two cultured human cell lines (HepG2 and MG-63). Lipid extracts were prepared from...
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