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To clarify physiological role of the carbon 3 (C-3) epimerization of 1α,25(OH) 2 D 3 and biologic significance of a 3-epi metabolite of 1α,25(OH) 2 D 3 , we examined biologic activities of the 3-epimers of 1α,25(OH) 2 D 3 and 1α,25(OH) 2 -16-ene-D 3 analogs in terms of modulation of cell cycle phase distribution and cell-surface CD11b...
1α,25-Dihydroxyvitamin D 3 (1α,25(OH) 2 D 3 ) has been shown to modulate not only proliferation and differentiation but also apoptosis of malignant cells, indicating that it would be useful for the treatment of hyperproliferative diseases such as cancer and psoriasis. Little information is available concerning structural motifs of the 1α,25(OH) 2 D 3 molecule...
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