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Inhibition of fatty acid synthase (FAS) has been proposed as a new therapeutic target for the treatment of cancer. In our preliminary study, a MeOH extract of the aerial parts of Orostachys japonicus A. Berger (Crassulaceae) inhibited FAS activity (>95% inhibition at 62.5μg/mL). Through bioassay-guided fractionation, we isolated three cerebrosides (1–3), including one new compound (1), and seven...
The effects of reactive oxygen species (ROS), especially hydroxyl radical (OH), on cellular wall disassembly in vitro and in vivo, and aril breakdown in longan fruit, were investigated. OH caused the disassembly of cell wall material (CWM) in vitro, demonstrated by the increases of total sugars and uronic acid released, and the downshift in molecular mass of CDTA soluble pectin (CSP) and Na 2...
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