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A photothermal genome‐editing strategy is described to improve immune checkpoint blockade (ICB) therapy by CRISPR/Cas9‐mediated disruption of PD‐L1 and mild‐hyperthermia‐induced activation of immunogenic cell death (ICD). This strategy relies on a supramolecular cationic gold nanorod that not only serves as a carrier to deliver CRISPR/Cas9 targeting PD‐L1, but also harvests the second near‐infrared‐window...
In article number 2006003, Yuan Ping and co‐workers, by means of photothermal transcription of CRISPR/Cas9 in the second near‐infrared window, demonstrate genome editing of PD‐L1 to be effective to reprogram the tumor microenvironment. The photothermal genome editing for the disruption of PD‐L1 mediated by supramolecular gold nanorods also simultaneously activates T cells to infiltrate and attack...
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