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Background and PurposePatients with major depressive disorder receiving racemic ketamine, (R,S)‐ketamine, experience transient increases in Clinician‐Administered Dissociative States Scale scores and a coincident drop in plasma d‐serine levels. The results suggest that (R,S)‐ketamine produces an immediate, concentration‐dependent pharmacological effect on d‐serine plasma concentrations. One potential...
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