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The quaternary benzo[c]phenanthridine alkaloid sanguinarine (SG) is the main component of Sangrovit ® , a natural livestock feed additive. Dihydrosanguinarine (DHSG) has recently been identified as a SG metabolite in rat. The conversion of SG to DHSG is a likely elimination pathway of SG in mammals. This study was conducted to evaluate the toxicity of DHSG in male Wistar rats at concentrations...
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