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MRI estimates of extracellular volume and tumor exudate flux in peritumoral tissue are demonstrated in an experimental model of cerebral tumor. Peritumoral extracellular volume predicted the tumor exudate flux.
Eighteen RNU athymic rats were inoculated intracerebrally with U251MG tumor cells and studied with dynamic contrast enhanced MRI (DCE‐MRI) approximately 18 days post implantation. Using a model...
The distribution of dynamic contrast‐enhanced MRI (DCE‐MRI) parametric estimates in a rat U251 glioma model was analyzed. Using Magnevist as contrast agent (CA), 17 nude rats implanted with U251 cerebral glioma were studied by DCE‐MRI twice in a 24 h interval. A data‐driven analysis selected one of three models to estimate either (1) plasma volume (vp), (2) vp and forward volume transfer constant...
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