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BackgroundExtracellular Adenosine‐5′‐Triphosphate (ATP) is known to accumulate in the lung, following allergen challenge, and contributes via activation of purinergic receptors on dendritic cells (DC), to the development of allergic airway inflammation (AAI). Extracellular ATP levels in the airways are normally tightly regulated by CD39. This ectonucleotidase is highly expressed by DC purified from...
To cite this article: Müller T, Robaye B, Vieira RP, Ferrari D, Grimm M, Jakob T, Martin SF, Di Virgilio F, Boeynaems J‐M, Virchow JC, Idzko M. The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation. Allergy 2010; 65: 1545–1553.
AbstractBackground: Extracellular ATP contributes to the pathogenesis of asthma via signalling at purinergic...
Background
The stable prostaglandin I2 analogue (iloprost) iloprost has been shown to inhibit allergic airway inflammation in mice by modulating the function of myeloid dendritic cells (DCs).
Objective
The aim of the current study was to investigate the biological activity of iloprost on human monocyte‐derived DCs.
Methods
I prostanoid (IP) receptor expression was analysed by RT‐PCR...
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