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BackgroundClinical data suggest gender differences in gastrointestinal pain, but very little experimental data exist. Esophageal painful thresholds to mechanical, thermal, electric, and chemical stimuli can be measured with the esophageal multimodal pain model. The aim was to measure the effect of gender and mild esophagitis on esophageal pain perception.
MethodsThirty‐five healthy asymptomatic volunteers...
Background and aims. To develop a pain model for chemical stimulation of the human gut.Methods. In a double-blind experimental study 10 subjects with a previously performed sigmoidostomy were randomised to receive injections with either isotonic or hypertonic saline in the colonic mucosa. In the hypertonic experimental arm, 0.1ml of 0.9%, 2%, 4%, and 6% and 0.2ml of 2% and 4% saline were given. In...
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