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Autophagy is a stress-induced cellular recycling mechanism that occurs at a basal level in all eukaryotic cells. Type I interferons are cytokines that have the ability to induce antiviral, antiproliferative and immunomodulatory activities in cells. Recently, we found that treatment with IFN-alpha2c and IFN-beta induces autophagy in Daudi B cells, starting at 24h as indicated by an increase of autophagy...
Hypoxic pulmonary vasoconstriction is associated with but may not be sufficient for the development of high-altitude pulmonary oedema (HAPO). Hypoxia is known to induce an inflammatory response in immune cells and endothelial cells. It has been speculated that hypoxia-induced inflammatory cytokines at high altitude may contribute to the development of HAPO by causing capillary leakage in the lung...
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