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Die zentrale Rolle der B-Lymphozyten in der Pathogenese des systemischen Lupus erythematodes (SLE) hat in den letzten Jahren das Interesse insbesondere auf spezifischere, B-Zell-gerichtete Therapien gelenkt. Belimumab ist ein monoklonaler Antikörper gegen den B-Lymphozytenstimulator BLyS, der 2011 als Zusatztherapie bei erwachsenen Patienten mit SLE zugelassen wurde. Auf Basis des aktuellen Kenntnisstands...
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