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Objectives: In order to compare the pharmacokinetics of two transdermal estrogen replacement therapy (ERT) systems designed to release 50 μg 17β-estradiol/day, two studies were performed in healthy postmenopausal volunteers. Methods: Both studies had a cross-over design and incorporated a 1-week wash-out period between treatments. In the first study, Menorest® 50 and Systen® 50 (Evorel® 50) were compared...
Postmenopausal osteoporosis is a progressive disorder characterized by a decreased bone mass and increased susceptibility to fractures. Several investigations have suggested that one of the mechanisms through which estrogen prevents bone loss was a modulation on secretion or release of various cytokines that are known to influence bone remodeling, even if some recent data have challenged this hypothesis...
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