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We have studied how various drugs increasing the rate of nicotinic acetylcholine receptors (nAChRs) lateral diffusion affect the depression of ACh-induced current in land snail Helix lucorum neurons responsible for defensive behavior. The acetylcholine (ACh) iontophoretic application protocol imitated the behavioral habituation protocol for the intact animal. We found that the drugs decreasing cholesterol...
The experimental relationship between the paired-pulse ratio of acetylcholine-induced inward currents in the command neurons of Helix lucorum and the interval between application of a neurotransmitter was analyzed using the method of paired-pulse stimulation. A mathematical model that takes the membrane and intracellular localization of receptors, their lateral diffusion, and endocytosis and exocytosis...
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