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Purpose of Review Recent findings regarding major histocompatibility complex (MHC) class II polymorphisms, sources of peptides, and regulation of expression on human pathologies are described with regards to impacts on human health. Recent Findings Studies of MHC class II polymorphisms associated with disease indicate that beyond the selection of loaded peptide, sequence variations affect the ability...
Activation of class II major histocompatibility complex (MHC) gene expression is regulated by a master regulator, class II transcriptional activator (CIITA). Transactivation by CIITA requires its nuclear import. This study will address a mechanistic role for the leucine-rich repeats (LRR) of CIITA in regulating nuclear translocation by mutating 12 individual consensus-motif ''leucine'' residues in...
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