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Key points
Maternal resveratrol (RESV) administration in gestational diabetes (GDM) restored normoglycaemia and insulin secretion.
GDM‐induced obesity was prevented in male GDM+RESV offspring but not in females.
GDM+RESV offspring exhibited improved glucose tolerance and insulin sensitivity.
GDM+RESV restored hepatic glucose homeostasis in offspring.
Glucose‐stimulated insulin secretion was enhanced...
Key points
Gestational diabetes mellitus is a common complication of pregnancy, but its effects on the offspring are poorly understood.
We developed a rat model of diet‐induced gestational diabetes mellitus that recapitulates many of the clinical features of the disease, including excessive gestational weight gain, glucose intolerance, hyperinsulinaemia and mild hyperglycaemia.
Compared to the offspring...
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