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Influenza viruses belong to the Orthomyxoviridae family and cause acute respiratory distress in humans. The developed drug resistance toward existing drugs and the emergence of viral mutants that can escape vaccines mandate the search for novel antiviral drugs. Herein, the synthesis of epimeric 4′‐methyl‐4′‐phosphonomethoxy [4′‐C‐Me‐4′‐C‐(O‐CH2P═O)] pyrimidine ribonucleosides, their phosphonothioate...
The lack of effective therapies for epileptic patients and the potentially harmful consequences of untreated seizure incidents have made epileptic disorders in humans a major health concern. Therefore, new and more potent anticonvulsant drugs are continually sought after, to combat epilepsy. On the basis of the pharmacophoric structural specifications of effective α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic...
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