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We conducted a study to assess pharmacokinetics of high‐dose tranexamic acid for 24 h after administration of the drug in patients undergoing cardiac surgery with cardiopulmonary bypass. High‐dose tranexamic acid involved a bolus of 30 mg.kg−1 infused over 15 min followed by a 16 mg.kg−1.h−1 infusion until chest closure with a 2 mg.kg−1 load within the pump prime. Tranexamic acid followed first‐order...
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