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AimIn the present study, we aimed to elucidate the effects of chronic vasopressin administration on renal medullary oxygen levels.
MethodsAdult Sprague Dawley or vasopressin‐deficient Brattleboro rats were treated with the vasopressin V2 receptor agonist, desmopressin (5 ng/h; 3d), or its vehicle via osmotic minipumps. Immunostaining for pimonidazole and the transcription factor HIF‐1α (hypoxia‐inducible...
AimVon Hippel‐Lindau protein (VHL) provides the degradation of hypoxia‐inducible factor (HIF). Tetracycline‐induced, Pax8‐rtTA‐based knockout of VHL (VHL‐KO) affects all renal tubules and periportal hepatocytes and leads to sustained upregulation of HIF. Here, we study the phenotype of VHL‐KO in both organs, the time course of changes, and long‐term morpho‐functional outcome.
MethodsMice with doxycycline‐induced...
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