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AbstractA total of 66 skin biopsies from persons with Alzheimers disease (AD) or Downs syndrome (DS) and from persons without AD were used in this study. The age range was from 7 to 89 years. Positive immunoreactivity of skin biopsies to monoclonal antibody 4G8, which is reactive to amino acid residue 1724 of synthetic amyloid protein (A), and 4G8-Fab (the antigen-binding fragment of 4G8 IgG, reactive...
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