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The underlying mechanism of coexistence of hepatitis B surface antigen (HBsAg) and hepatitis B surface antigen antibody (anti‐HBs) is still controversial. To identify the host genetic factors related to this unusual clinical phenomenon, a two‐stage study was conducted in the Chinese Han population. In the first stage, we performed a case‐control (1:1) age‐ and gender‐matched study of 101 cases with...
Summary. The aim of the present study was to authenticate the involvement of DNA methyltransferases (DNMTs) and methyl‐CpG binding domain protein 2 (MBD2) in the process of HBx induced p16INK4A promoter hypermethylation in HBV‐related hepatocellular carcinoma (HCC) and their corresponding noncancerous liver tissues. Eighty‐eight fresh tissue specimens of surgically resected HBV‐associated HCC and...
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